Deleting an inhibitory gene in natural killer cells derived from induced pluripotent stem cells is found to boost their anti-tumor activity and persistence; researchers now seek to develop a clinical therapy
Putting ‘super’ in natural killer cells
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Gene Therapy
Researchers model human stem cells to identify degeneration in glaucoma
Using human stem cell models, researchers found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process
Researchers develop ‘piggyback’ vehicle to deliver RNA therapeutics
Researchers have developed a new way to deliver molecules that target specific genes within cells. Their platform, which uses a modified form of diphtheria toxin, has been shown to downregulate critical genes in cancer cells, and could be used for other genetic diseases as well
Scientists program cells to carry out gene-guided construction projects
Researchers have developed a method to genetically reprogram cells to build artificial structures
A step toward a better way to make gene therapies
New method for delivering DNA into stem cells and immune cells safely, rapidly and economically
A novel method to precisely deliver therapeutics inside the body
Researchers are interfacing chemical biology and nanotechnology to develop ultrasound-controlled nanomaterials that can provide on-demand, high precision delivery of proteins into human cells
Targeting multiple brain cell types through engineered viral capsids
Researchers have now developed a method to rapidly and efficiently identify designer adeno-associated virus (AAV) variants that can deliver to or “transduce” specific types of cells in mice, enabling scientists to choose a virus based on research or clinical needs
Beta cells from stem cells: Potential for cell replacement therapy
Researchers developed an improved pluripotent stem cell differentiation protocol to generate beta cells in vitro with superior glucose response and insulin secretion. This is a major step towards beta cell replacement therapy
Diabetes reversed in mice with genetically edited stem cells
CRISPR corrects genetic defect so cells can normalize blood sugar