Reviewed by Heidi Declercq
V Salih eds.
The book “Standardisation in cell and tissue engineering” is a valuable contribution in the field of biomaterials and tissue engineering.
In the final goal to replace or regenerate a lost/diseased organ, the high amount of tissue engineering activity did not result in an equal number of commercially available products. In this regard, standardization is a prerequisite for successful clinical translation.
The book is divided in 2 parts: 1) Methods for cell and tissue engineering and 2) Standards and protocols in cell and tissue engineering.
In the first part, the fundamentals of cell and matrix biology for tissue engineering are described followed by the development of a biomatrix. Two-dimensional and 3-dimensional bioprocessing methods (bioreactors) are applied for soft and hard tissue engineering. A special focus is given on the mass transfer in tissue engineering bioreactors and the important parameters that should be measured. Of particular interest is chapter 5 describing the importance of vascularization of tissue-engineered constructs.
In the second part, standards on how to characterize scaffolds and cells are described as well as how to proceed towards commercialization of cell-based products. The chapter regarding the sterilization procedure is only dealing with ionizing radiation. It would be more interesting if several sterilization methods were described and their effect on biomaterials.
The book is a comprehensive overview of the current standards in cell and tissue engineering, and biomaterials, which is of interest to a broad public including biologists, biomedical engineers and chemists.
Tissue Engineering Group, Ghent University